Genetics of Human Disease

Catalog description

Students will gain a mastery of linking molecular genetic changes to human disease phenotypes. This course will revisit concepts of Mendelian genetics and apply the various complex patterns of heritable traits. Students will investigate the eukaryotic gene organization, structure and function by analyzing the levels of central dogma with genomic and transcriptomic data in model organisms and humans. Students will evaluate how molecular and cellular changes can be determinants of various human diseases. Students will gain an understanding of how therapeutic interventions manipulate genetic and cellular machinery. Students will utilize a well-annotated genome browser and analyze primary literature to understand human genetic disease diagnosis, prognosis and treatment. Prequisites: BIO-110/Lab and BIO-111/Lab